Performance Solvents for the pharmaceutical industry

For more than 60 years, leading pharmaceutical companies have relied on Haltermann Carless as a trusted manufacturer of high-purity hydrocarbons. With purities of up to 99.75%, our solvents meet even the most stringent requirements – supporting you reliably in the production of pharmaceuticals and active pharmaceutical ingredients (APIs).

Our modern, certified production sites in Europe ensure absolute reliability, compliance, and products of the highest standard. Thanks to their exceptional purity, our solvents enable precise control of synthesis steps – a decisive advantage for your manufacturing process.

We continuously invest in our facilities and develop application-oriented solutions, so you can count on the highest standards and a true partnership – today and in the future.

Die Pharmaindustrie

Die pharmazeutische Industrie gehört zu den wichtigsten Wirtschaftszweigen und hat auch gesellschaftlich einen hohen Stellenwert. Mit der Herstellung einer großen Bandbreite an pharmazeutischen Produkten im Bereich der Human- und Veterinärmedizin, trägt sie einen großen Teil zu gesellschaftlichen Verbesserungen, wie

einer steigenden Lebenserwartung,
weniger Neuerkrankungen oder
geringeren Arbeitsausfällen bei.

Bei den Produkten handelt es sich um Arzneimittel oder Medikamente, deren Wirkstoffe oder Wirkstoffkombinationen zur Verbesserung, Erhaltung oder Wiederherstellung der Gesundheit dienen, z.B. Fertigmedikamente, Impfstoffe oder auch biotechnologisch erzeugte Gentherapeutika. In die Herstellung dieser unverzichtbaren Produkte investiert die Pharmabranche jährlich beachtliche Summen speziell in die Forschung und Entwicklung. Besonders in diesem Bereich ist die chemische Industrie ein wichtiger Lieferant von unterschiedlichsten Grundstoffen.

Our products for
pharmaceutical applications

Our high-purity paraffins are used in the production of active pharmaceutical substances - also known as active ingredients (API). Both long-chain n-Paraffins and branched Isoparaffins are used.

A good example is n-Heptane. This paraffin is not used directly as a solvent in the reaction, but in processing, crystallisation, washing of purified substances and extraction. It is also a popular solvent for HPLC (High Performance Liquid Chromatography) applications. Instead of n-Heptane, n-Octane or the isoparaffin Iso-Octane can often be used. Besides n-Heptane and the octanes, n-Pentane and n-Hexane are also used.

Which solvent is chosen depends mainly on the different physical properties of the molecules.

High-purity solvent characteristics

In the pharmaceutical industry 99% pure products are the standard. The remaining molecules boil in a similar range. As they are saturated molecules, our Performance Solvents do not interfere with any reaction or application. For an even higher performance we also offer our paraffinic solvents with a purity of >99%.

Our range of 95% and 99% hydrocarbons offers a comprehensive selection of products that meet the highest purity and quality requirements of the pharmaceutical industry. C5 to C8 are of great importance for the pharmaceutical industry, especially n-Heptane.

The physical properties of these products are fine-tuned. The product line includes

aliphatic,
cyclic and
aromatic hydrocarbons with chain lengths ranging from C5 to C16.

Hydrocarbons 95%

Hydrocarbons 95%	CAS-No.	Colour	Density	Destillation Rate	Evaporation Rate	Refractive Index	Anilin Point	Aromatic content	Non-Volatile Matter	Flash Point	Vapor Pressure	Kinetic Viscosity
Typical Properties		ISO 6271	@ 15°C kg/m³ ISO 12185	°C @ 101.3 kPa ASTM D 1078	(Ether = 1) DIN 53170	ⁿD²⁰ DIN 51423-2	°C ISO 2977	% m/m GC/UV-Spectroscopy	mg/100ml DIN 53172/ASTM D 1353	°C ISO 2719/ISO 13736	kPa @ 20°C (1 kPa = 10mbar)	mm²/s (cSt) @ 20°C ISO 3104
n-Heptane	142-82-5	< 5	688	97-100	3.1	1.388	70	< 0.02	< 2	< -4	3.9	0.58
iso-Octane (2,2,4-Trimethylpentane)	540-84-1	< 5	696	98-101	2.9	1.392	79	< 0.01	< 2	-10	3.7	0.68
n-Octane	111-65-9	< 5	708	124-127	8.0	1.398	73	< 0.01	< 5	+12	1.3	0.74
iso-Pentane	78-78-4	< 5	624	27-29	< 1.0	1.354	-	< 0.001	< 2	< -20	56.9	0.35
n-Pentane	109-66-0	< 5	631	36-38	1.0	1.358	69	< 0.01	< 2	< -20	40.9	0.39
n-Hexane	110-54-3	< 5	665	68-70	1.5	1.375	68	< 0.01	< 2	< -20	12.5	0.47
n-Octane	111-65-9	< 5	708	124-127	8.0	1.398	73	< 0.01	< 5	+12	1.3	0.74
n-Nonane	111-84-2	< 5	723	150-154	24.0	1.405	74	< 0.03	< 5	-30	0.38	0.96
n-Decane	124-18-5	< 10	733	172-177	67.0	1.412	77	< 0.01	< 5	+45	0.16	1.12

Hydrocarbons 99%

Hydrocarbons 99%	CAS-No.	Molecular Weight	Density	Boiling Point	Solidification Point	Refractive Index	Flash Point	Specific Heat	Heat of Vaporization	Vapour Pressure 25°C	Surface Tension	Kinemtic Viscosity
Typical Properties			at 20°C kg/m³ ISO 12185	at 101.3 kPa (1013 mbar) °C	°C	ⁿD²⁰ DIN 51423-2	°C ISO 2719/ISO 13736	cp kJ/kg.K at 20°C (1kj = 0.239 kcal)	ΔH kJ/kg (1 kJ = 0.239 kcal)	kPa @ 25 °C (1kPa = 10mbar)	@ 20°C mN/m (dyn/cm)	mm²/s (cSt) @ 20°C ISO 3104
n-Heptane	142-82-5	100.2	684	98.4	-90.6	1.3875	-1	2.208	316.5	6.26	19.3	0.61
iso-Octane (2,2,4-Trimethylpentane)	540-84-1	114.2	692	99.3	-71.8	1.3915	-12	2.074	271.6	6.04	18.8	0.70
n-Octane	111-65-9	114.2	705	125.7	-56.8	1.3975	+12	2.196	301.1	2.00	21.8	0.78
iso-Pentane	78-78-4	72.1	620	27.8	-160.0	1.3540	< -35	2.258	339.0	91.74	15.0	0.36
n-Pentane	109-66-0	72.1	626	36.0	-131.0	1.3575	< -35	2.372	357.5	68.39	16.0	0.38
n-Hexane	110-54-3	86.2	660	68.7	-95.3	1.3750	-23	2.263	335.1	20.24	18.4	0.47
n-Nonane	111-84-2	128.3	718	150.8	-53.5	1.4054	+31	2.108	286.5	0.66	22.9	1.00
n-Decane	124-18-5	142.3	730	174.1	-29.7	1.4120	49	2.103	276.3	0.23	23.9	1.27

Certified quality

Our Hamburg laboratory is accredited according to ISO/IEC 17025. This is particularly important for our customers in the pharmaceutical chemistry sector, where the highest standards of quality and purity must be maintained.

This includes individually tailored specifications and mixtures in which, certain trace molecules are detected. We can also perform tests for oxygen-containing molecules such as ketones.

We are aware of the special requirements and always strive to meet them, for example through regular internal and customer audits of globally leading companies and specialist manufacturers.

We at Haltermann Carless see audits as opportunities to review and improve our quality processes. The positive results speak for themselves and ensure that we have been a reliable supplier and strong partner of many of our customers for decades.

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Double quality check

A further special feature is the double quality check, which we carry out in our laboratories at our production sites. This means that quality is checked during and after production as well as before delivery to our customer.

In addition, there is the four-eye principle in the laboratory. The measured analysis results are checked by a second laboratory employee before the result is entered in the report.

The production of
high-purity hydrocarbons

In our production of extremely high-purity hydrocarbons, we comply with the world's most stringent production and quality standards. All our production sites are certified to ISO 9001, ISO 14001 and ISO 50001 as part of our quality management system. Our products are manufactured "Made in Europe" and in the pharmaceutical industry "Made in Germany". For us, this also means maintaining our high standards and continuously investing in the future.

Production site Speyer

We have recently invested in a modern and flexible hydrogenation unit at our production site in Speyer, Germany. The hydrogenation plant offers many opportunities to grow further in the future and to meet the increasing demands of the pharmaceutical industry.

In the hydrogenation plant, the unsaturated carbon bonds contained in the raw material are converted into saturated ones by reaction with hydrogen. This allows new product types and products to be produced with a high degree of purity. The hydrogenation unit offers a further advantage in its high production flexibility, as it opens up new possibilities in the supply of raw materials.

More insights on our Speyer site

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Production site Speyer

We do this, for example, at the production site of Haltermann Carless in Speyer. Here our modern and flexible hydrogenation plant offers → many opportunities to grow further in the future and to meet the increasing demands of the pharmaceutical industry, for example.

In the hydrogenation plant, the unsaturated carbon bonds contained in the raw material are converted into saturated ones by reaction with hydrogen. This allows new product types and products to be produced with a high degree of purity. The hydrogenation plant offers a further advantage in its high production flexibility, as it opens up new possibilities in the supply of raw materials. This contributes to the strategic stability of the business and to maintaining competitiveness on the international market.

Learn more about the production site Speyer

Umfangreiche Serviceleistungen von der Produktion über die Qualitätskontrolle bis zur Transportlogistik

Unsere Traditionswerte wie Kundenfokus, Individualität oder Zukunftsorientiertheit setzen wir in allen unseren Fachbereichen um. Der Dialog mit unseren Kunden und Lieferanten ist uns dabei besonders wichtig. Nur gemeinsam können wir bestmögliche Lösungen für die Bedürfnisse der Farben-, Lack- und Klebstoffindustrie finden.

Zusätzlich zu den Leistungen in unseren Laboratorien bietet Haltermann Carless individuellen Service und Beratung bei Spezifikationen und Formulierungen, im Bereich Supply Chain oder Produktinformationen, aber auch bei Fragen rund um REACH, Zertifikate oder Regularien.

Um unseren Kunden leistungsstarke Produkte und Komplettlösungen für ihre individuellen Anforderungen bieten zu können, setzen wir auf:

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Trends

Wir denken zukunftsorientiert, wie schon unsere Gründerväter. Digitalisierung ist bei Haltermann Carless ein zentraler Fokus, den wir besonders im Bereich Supply Chain beispielswiese mit Time-Slot-Management oder Track & Trace-Systemen aktiv vorantreiben. Trends sind uns aber auch im Bereich Nachhaltigkeit wichtig: Unsere moderne Hydrieranlage mit nachhaltiger Technologie am Standort Speyer ermöglicht es, neuartige Produkte und Prozesse noch umweltfreundlicher herzustellen. Und wir gestalten aktiv an der Zukunft der Chemieindustrie in Europa mit. Wir engagieren uns in diversen Verbänden und Arbeitskreisen und erfahren Trends aus erster Hand. So sind wir für unsere Kunden und die Zukunft gut aufgestellt!

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Performance Solvents for the pharmaceutical industry

Maximum product purity for the most demanding pharmaceutical applications.

Die Pharmaindustrie

Haltermann Carless offerings
to the pharmaceutical industry:

Our products for
pharmaceutical applications

Portfolio:

Pioneers don’t just deliver.
They generate impact.